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SMOFlipid 20%

SMOFlipid 20%

Manufacturer:

Fresenius Kabi

Distributor:

Zuellig
/
The Glory Medicina
Concise Prescribing Info
Contents
Per L Refined soya bean oil 60 g, medium-chain triglycerides 60 g, refined olive oil 50 g, fish oil (omega 3) 30 g
Indications/Uses
Supply of energy, essential fatty acids & omega-3 fatty acids to patients as part of parenteral nutrition regimen when oral or enteral nutrition is impossible, insufficient or contraindicated.
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Dosage/Direction for Use
IV infusion into peripheral or central vein. Adult 1-2 g fat/kg daily at an infusion rate of 0.125 g fat/kg/hr. Max infusion rate: 0.15 g fat/kg/hr. Childn Max daily dose: 3 g fat/kg. Gradually increase daily dose during the 1st wk of therapy. Max infusion rate: 0.15 g fat/kg/hr. Neonate & infant Initially 0.5-1 g fat/kg daily followed by successive increase of 0.5-1 g fat/kg daily up to 3 g fat/kg daily. Max daily dose: 3 g fat/kg. Max infusion rate: 0.125 g fat/kg/hr. For premature & low birth wt neonates, continuously infuse over 24 hr.
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Overdosage
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Contraindications
Hypersensitivity to fish, egg, soya or peanut protein. Severe hyperlipidemia; severe liver insufficiency; severe blood coagulation disorders; severe renal insufficiency w/o access to hemofiltration or dialysis; acute shock; acute pulmonary oedema, hyperhydration, decompensated cardiac insufficiency; unstable conditions eg, severe post-traumatic conditions, uncompensated DM, acute MI, stroke, embolism, metabolic acidosis, severe sepsis & hypotonic dehydration.
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Special Precautions
Immediately interrupt infusion in case of any sign or symptom of anaphylactic reaction. Monitor capacity of patient to eliminate fat. Caution in patient w/ marked risk for hyperlipidemia eg, patients w/ high lipid dosage, severe sepsis & extremely low birth wt infant; in conditions of impaired lipid metabolism eg, in patient w/ renal failure, DM, pancreatitis, liver impairment, hypothyroidism & sepsis; neonate & premature neonate w/ hyperbilirubinemia & pulmonary HTN. Risk of metabolic acidosis. Simultaneous infusion of carbohydrate or a carbohydrate-containing amino acid soln is recommended. Monitor blood glucose levels, LFTs, acid-base metabolism, fluid balance, FBC & electrolytes. High levels of lipids in plasma may interfere w/ some lab blood tests eg, Hg. Pregnancy & lactation.
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Adverse Reactions
Slight increase in body temp.
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Drug Interactions
Heparin given in clinical doses causes a transient increase in lipoprotein lipase release into the circulation, which may initially result in increased plasma lipolysis, followed by a transient decrease in triglyceride clearance.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view SMOFlipid 20% detailed prescribing information
Storage
View SMOFlipid 20% storage conditions for details to ensure optimal shelf-life.
Description
View SMOFlipid 20% description for details of the chemical structure and excipients (inactive components).
MIMS Class
Parenteral Nutritional Products
ATC Classification
B05BA02 - fat emulsions ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.
Presentation/Packing
Form
SMOFlipid 20% emulsion for infusion
Packing/Price
100 mL x 1's
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